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US study links chemical to sperm damage

16.12.2002
Chemické látky
US study links chemical to sperm damage
WASHINGTON - Everyday exposure to a chemical ingredient used to preserve many cosmetics and fragrances may contribute to sperm damage in adult men, according to a study published.
In one of the first studies of the effects of substances known as phthalates on humans, Harvard University researchers found signs of correlation between exposure to a common type of the chemical and damage to the DNA of human sperm. The study, published in the government journal Environmental Health Perspectives, does not show whether this DNA damage could leave men infertile or cause birth defects, the researchers said. Last month, the U.S. Cosmetic Ingredient Review panel, an industry-sponsored watchdog, sparked fury from health and environmental lobbyists when it voted to allow the continued use of three types of phthalates in perfumes and beauty products, saying they were safe in their current uses. Phthalates, used to make fragrances last longer and to soften plastics like baby toys, have been linked in previous studies to birth defects in animals, but no evidence has proved they are harmful to humans. The American Chemistry Council maintains that phthalates are safe and the U.S. government so far has declined to limit their use. But the European Union banned their use in some products, including baby toys, in 1999. The study, conducted at a Massachusetts fertility clinic, analyzed urine and semen samples from 168 men believed to have normal levels of exposure to diethyl phthalates through the use of cosmetics products and plastics. Russ Hauser, a Harvard University School of Public Health professor and senior author of the study, said preliminary results suggested exposure to those phthalates was associated with increased DNA damage in sperm, but said it was too early to tell how severe the damage was. \"What the significance of it is, we don\'t know. What it predicts in terms of end points in the fetus or child is really unclear at this point,\" he said in a telephone interview. Hauser said his group planned to extend its research to include between 700 and 800 men in order to verify the findings, and to cross-reference results with findings of other studies measuring factors like pregnancy success rates. \"This paper shows early findings in a relatively small number of men,\" he said. \"Our next step here really is to expand the study, and repeat the analyses.\" But a group that has been fighting the use of phthalates, Health Care Without Harm, said the study showed they were right. \"The correlation found in this study is extremely troubling and deserves urgent follow up,\" Dr. Ted Schettler, science director of the Science and Environmental Health Network said in a statement on behalf of the group. Story by Laura MacInnis REUTERS NEWS SERVICE
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